Without it, bone loss often happens (more about this next). More serious letrozole side effects are also possible. Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP. But its also sometimes prescribed to help treat other PCOS-related conditions, such as elevated blood sugar levels and insulin resistance. You may also experience side effects caused by other treatments or individual circumstance, such as the menopause. Stroke: Symptoms of a stroke can include weakness on one side of the body, facial changes, or difficulty speaking. Some of these include bone fractures and complications from high cholesterol. Went to a urogyn who said this is a result of the tissues thinning from lack of estrogen. During studies of letrozole, headaches were a common side effect in people taking the drug. skin hypersensitivity. Both medications belong to a group of drugs called aromatase inhibitors. Cerner Multum, Inc. "UK Summary of Product Characteristics." Also, you can apply an ice pack or heat pad to your head to help ease the headache. These symptoms usually improve or become easier to manage over time. It comes as oral tablets that youll swallow. "Product Information. Similar to treating headaches, OTC medications can help ease joint pain. About 30% of people reported hot flashes when using letrozole for breast cancer. The stress of the breast cancer and the initial treatment, whether it was surgery, chemo (with steroids of course), radiotherapy or all 3 will have contributed to raised levels at the time. , 7 , ? However, doctors found that it also induces ovulation, so, since 2000, it has been used off-label to help women with fertility issues. Our phase IV clinical studies alone cannot establish cause-effect relationship. Along with its needed effects, oxybutynin (the active ingredient contained in Oxytrol) may cause some unwanted effects. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Swallow the tablet with a drink of water. The risk of myocardial infarction with aromatase inhibitors relative to tamoxifen in post-menopausal women with early stage breast cancer. For instance, if you have hot flashes or nausea with letrozole, you can try reducing the amount of spicy or rich foods you eat. Find out more aboutlooking after your bones and osteoporosis . A physiotherapist may also be able to suggest exercises to help. Medicine Assistance Tool and NeedyMeds are two websites that provide resources to help reduce the cost of letrozole oral tablets. If you think you have fatigue, tell your GP or treatment team. contain a code you can scan with a smartphone to change the text to audio. Avoid driving or hazardous activity until you know how letrozole will affect you. So while they might improve hot flashes, they could interfere with how letrozole works. Descriptions Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). Keep using birth control for at least 3 weeks after your last dose of letrozole. To help keep your bones healthy you can increase your intake of calcium and vitamin D. Most people do this by taking a supplement. Because letrozole lowers estrogen levels, it can cause bone loss as a side effect. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. Traditional chemotherapy agents stop cancer cells from growing, dividing, and making more cells. But be sure to talk with your doctor before stopping this drug. This causes pain, tingling and numbness in your arm, hand or fingers. Avoid alcohol as it may make you feel more tired and drowsy. It most commonly occurs when changing from one hormone therapy to another. These factors include what your insurance plan covers and which pharmacy you use. Some of the tablets may have different additional ingredients (for example preservatives). These side effects can often be managed with lifestyle changes. Although not all of these side effects may occur, if they do occur they may need medical attention. In clinical studies, people with liver disease had higher levels of letrozole in their body. There are CDs, podcasts and phone apps that can guide you through these techniques. As mentioned above, low estrogen levels can lead to bone loss. 31 Aug 2021 13:51 in response to EllieJ. PCT is used to help minimize side effects that bodybuilders have when they take anabolic steroids to build muscles. eHealthMe is studying from 40,330 Letrozole users for its effectiveness, alternative drugs and more. A healthy diet and exercise can help lower your cholesterol. Letrozole can cause high blood pressure (hypertension) in some people. Letrozole is also used off-label for certain types of infertility. Sign up for our GoodRx Diet and Nutrition Newsletter to receive the latest healthy eating advice, recipes, and savings that are most relevant to you. Some studies show that turmeric may help fight infections and some cancers. Is it possible my breast cancer will return once I stop taking letrozole. Its prescribed for adult females* whove gone through menopause. But if you think youre having a medical emergency, you should call 911 or your local emergency number. (2016). Different individuals may respond to medication in different ways. 3. Food doesnt interact with letrozole. Everyone reacts differently to drugs and some people have more side effects than others. Continue reading, When you stop taking letrozole, most persistent side effects should improve within a week or 10 days, and as long as you have taken it for at least 5 years, then letrozole should continue to reduce the risk of breast cancer coming back for many years after you stop taking it. You may also want to eat more foods that are rich in calcium, such as milk, cheese, yoghurt and cereals. Unlike letrozole, clomiphene is approved for this use. If dizziness persists see your GP. constipation, diarrhea, decreased urination. This drug may cause weak bones. Bryant Ranch Prepack. Healthline Media does not provide medical advice, diagnosis, or treatment. If you continue to have difficulty sleeping your GP may prescribe something to help you sleep. Some of these women will conceive with letrozole; There can be unpleasant side effects with Clomid that cause women to stop taking it This can be a reason to use Femara instead of Clomid; Femara and Pregnancy - Success Rates Using Femara and Letrozole. Generic name: letrozole [LET-roe-zol] Letrozole and other drugs in the same group of medications commonly cause joint pain and stiffness. Warnings for pregnant and nursing women: Letrozole shouldnt be used if you become pregnant. Learn. Studies havent shown metformin to be useful when used by itself for infertility. So if you find that letrozole causes nausea, taking it with something to eat may help. Added to Saved items. Among them, 1,159 people (2.91%) have Urinary tract infection. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Estrogen typically prevents your ovaries from ovulating (releasing an egg). Talk with your doctor or pharmacist if you have questions about taking supplements or other ways to prevent or manage weakened bones. Letrozole oral tablets may not be right for you if you have certain medical conditions or other factors that affect your health. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of letrozole oral tablets. European Journal of Cancer. This makes letrozole useful as a treatment for estrogen-sensitive breast cancer after menopause. In studies of letrozole for PCOS-related infertility, about 20% reported this side effect. If you have questions about using letrozole in bodybuilding or for endometriosis, talk with your doctor. Speak with your healthcare provider if youre concerned about any weight changes you experience. These could include weakened bones, for example. Colitis can be caused by bacterial infections, viruses, and autoimmune disorders. Specifically, its called an aromatase inhibitor. Chemotherapy drugs are also a type of cancer treatment. How to Reduce Your Risk of Breast Cancer: 10 Lifestyle Recommendations, Symptoms of Late Stage Metastatic Breast Cancer, What to Know and Consider Before Having Prophylactic Mastectomy. Theyll also explain how much to take and how often. Letrozole. You may also experience weight gain with letrozole if you have swelling, which is another possible side effect of the drug. Like hot flashes, night sweats can happen when estrogen levels are low. Teeth-related side effects werent reported with letrozole use during studies. Their risk is higher because of the cancer itself and some treatments for breast cancer. Estrogen is important for bone health. Mild pain relief such as paracetamol may help with headaches. Letrozole is often used to treat infertility thats caused by polycystic ovarian syndrome (PCOS). Tell your doctor if you think you may be pregnant. Tell your doctor about all your current medicines and any medicine you start or stop using. You shouldnt take letrozole while youre pregnant or breastfeeding. Letrozole oral tablets are a generic drug, which means theyre an exact copy of the active drug in a brand-name medication. However, there are steps you can take to reduce your risk. Letrozole causes a reduction in estrogen, follicle stimulating hormone and luteinizing hormone in women with polycystic ovary syndrome or who have had an abnormal response to clomiphene citrate, and in men with advanced prostate cancer. But both cancer cells and healthy cells in your body can quickly multiply. Phytoestrogens act like estrogen in the body. Letrozole is sometimes used off-label to treat infertility in females. Side effects tend to go away once letrozole is stopped. But your doctor will recommend if its something you should do. Breast. (2014). Now, youll enjoy a streamlined experience created specifically for healthcare providers. But it can treat other forms of infertility, as well. Common letrozole side effects include hot flashes, night sweats, and muscle or joint pain. Heart attack or stroke: Over time, high cholesterol can raise your risk of more serious complications like a heart attack or stroke. If you have concerns about eating certain foods with letrozole, talk with your doctor. If you have questions about taking letrozole with other drugs, talk with your doctor. Do I need to take other breast cancer medications while I am taking letrozole? If you're having trouble, your doctor may prescribe a drug called letrozole. Because letrozole lowers estrogen levels, many of its side effects are similar to menopause symptoms. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The World Anti-Doping Agency prohibits athletes in competitive sports from using letrozole for non-approved uses. Also, if youre having trouble opening your medication bottles, let your pharmacist know. Letrozole [package insert]. Its typically taken by mouth once a day. It is often given to women who have been taking tamoxifen ( Nolvadex, Soltamox) for 5 years. Taking it at the same time each day will help you to remember your dose. No, there arent any specific foods you should avoid while youre taking letrozole. Factors to consider include those in the list below. If you have any worries or questions about taking or stopping letrozole, you can call us free on 0808 800 6000 to talk through your concerns. They work by decreasing the amount of the hormone estrogen in your body. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Night sweats may be annoying, but theyre not dangerous. Your GP or specialist can refer you for counselling or may suggest you take an antidepressant drug. Female hormones that occur naturally in the body can increase the growth of some breast cancers. Your pharmacist may also recommend tools to help make it simpler to open the drugs container. . If dizziness persists see your GP. If you feel dizzy, avoid driving. Low estrogen levels tend to cause hot flashes. The volume percentage of the smooth muscle component also changed, with a significant decrease at 1 week and then a gradual increase at 2 and 3 weeks. The phase IV clinical study analyzes which people take Letrozole and have Insomnia. Letrozole [package insert]. Check out this article to learn more about the differences between generic and brand-name drugs. In studies, joint pain was a common side effect of letrozole. Letrozole can sometimes cause headaches. Take calcium and vitamin D as you were told by your doctor. Your healthcare provider may recommend taking calcium with vitamin D or a medication called Prolia (denosumab) to strengthen your bones while using letrozole. Below are commonly used dosages, but always take the dosage your doctor prescribes. They work by killing cells in your body that quickly multiply (make more cells). A lack of oestrogen over time can causeosteoporosis. Other side effects You may find your side effects reduce after stopping letrozole, for others they may continue after treatment finishes. To understand diagnoses, you should understand breast cancer staging and what each means for overall outlook. Like any drug,letrozolecan cause side effects. So, letrozole doesnt need to be gradually stopped. If youre concerned about this you may find it helpful to speak to your specialist. Clomid is no longer available, but its generic version, clomiphene, is still available. 2023 eHealthMe.com. Common letrozole side effects can be frustrating, but theyre usually not serious. This list doesnt include all the possible side effects you could experience. What happens when you stop taking letrozole? Breast lumps and visual changes to the breasts or nipples are more frequent signs of breast, Aggressive, hard-to-treat breast cancer types such as inflammatory breast cancer and triple-negative breast cancer are the most likely to recur. In certain types of infertility like that caused by polycystic ovary syndrome (PCOS) an egg may not be released at the correct time, or at all. Its important to keep up with regular screenings for bone loss and cholesterol changes while taking letrozole. The brand-name medication that letrozole oral tablets are based on is called Femara. For example, it may be possible to switch to another aromatase inhibitor to see if your pain improves, or some people might be offered the drugtamoxifenas an alternative. Redness and swelling of your vagina and vulva. But sometimes, metformin is given together with clomiphene to help treat infertility in females with PCOS. Store at room temperature away from moisture and heat. Almost 15% of people using letrozole for breast cancer in clinical trials reported this side effect. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. You may have menopausal symptoms such as hot flushes, sweating, sleep disturbance, vaginal irritation such as dryness and itching, and reduced libido (sex drive). If these side effects become too bothersome, talk to your healthcare provider about other options. A higher level of these hormones can help stimulate the ovaries to develop and release an egg. Letrozole - side effects. Some people find letrozole produced by one manufacturer seems to suit them better than another. Heres a list of common questions related to taking letrozole. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Letrozole comes as tablets that youll take by mouth. Version: 8.02. Some other side effects of letrozole take a few months to develop and tend to persist long term until you stop taking letrozole. Some people who have taken oxybutynin medicines by mouth have had to be hospitalized. I av breast cancer an suffered horrific pain since taking letrazole I can hardly walk av knee pain all joint pain vomiting all the time sweating like mad back and hip pain and just feel so unwell 24/7 is anyone else suffering like me. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. They can also suggest ways to help reduce side effects. Some side effects may not be reported. Letrozole (Femara) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. We comply with the HONcode standard for trustworthy health information. Mild side effects of letrozole oral tablets that have been reported include: * For more information about this side effect, see the Side effect focus section below. Your pharmacist, GP or treatment team cantell you what products you can use on your skin to help. I have been on Anastrozole for 3 years and bladder pain has become my top issue. They are most common among people with weak immune systems. To learn about other mild side effects, talk with your doctor or pharmacist, or read letrozole oral tablets prescribing information. Sometimes it can go away on its own, but it can take months to get better. Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial. Letrozole can be taken with or without food. Instead, its a type of hormone therapy. Use the medicine exactly as directed. letrozole is for use only in women who can no longer get pregnant. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Letrozole blocks an enzyme (protein) called aromatase. Even if you transfer Candida onto another person, they likely won't develop a yeast infection unless they are already prone to the condition. generic drugs) are not considered. Letrozole may also make you feel sick (nausea) or be sick (vomiting). Usually, side effects from letrozole will be reduced after the first few months of treatment. Letrozole may also be used for purposes not listed in this medication guide. Recently, it has been utilized in infertile pre-menopausal women because of its ability to enhance FSH production for ovulation induction. What should be considered before taking letrozole? How Letrozole Is Given: Letrozole is a pill, taken by mouth. 1. Continue reading. Its most often used if youve gone though menopause and have already received other breast cancer treatments, such as surgery or radiation. Cancer-related fatigue is extreme tiredness that doesnt go away with rest or sleep. Your reactions could be impaired. Be sure to follow your doctors instructions. Since inflammation may be associated with joint pain, adding turmeric (mixed with freshly ground black pepper and olive oil for bioavailability) to foods or taking supplements may help relieve symptoms. Both letrozole and clomiphene are used to treat infertility in females* by helping to cause ovulation. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. The cells may even spread to other parts of your body. Some people benefit from switching to a different hormone therapy. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. Vaginal bleeding can happen in the first few weeks after starting letrozole. Many people feel low or depressed. For vitamin D, you can increase the amount of oily fish, mushrooms and eggs you eat. There isn't much you can do about the raised blood sugars caused by the Letrozole, and you will have to take the Letrozole for either 5 or 10 years. visible water retention temporary redness of face and neck weight gain headache nausea generalized weakness drug-induced hot flashes INFREQUENT side effects If experienced, these tend to have a. But it can still happen. GoodRx helps find the best price for you. Letrozole is an active drug, while Clomid was a brand-name medication that contained the active drug clomiphene. Yeast infections are caused by an overgrowth of a certain type of fungus, resulting. You may also want to check out the online communities at Bezzy. Report this post. I was checked for an infection but that came back clear. So, check with your doctor about the dosage of letrozole for infertility thats recommended for you. This does not change the effectiveness of the treatment. By taking proactive steps, like healthy eating and exercise, you may be able to prevent or manage weight gain from letrozole. This bone loss may cause joint pain. Do not use if you are pregnant. 39,784 people reported to have side effects when taking Letrozole. Melatonin and Breast Cancer: Is it Safe and Can it Help? Letrozole oral tablets can interact with several types of drugs. Last updated on Oct 9, 2022. Find answers to some commonly asked questions about letrozole oral tablets. High levels in liver disease: Letrozole is broken down by liver enzymes. Letrozole is made by a number of different manufacturers. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. If you have a history of high cholesterol you may want to discuss this with your specialist or GP. Doctor prescribes therapy to another feel sick ( nausea ) or be sick ( vomiting.. 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Flashes, they could interfere with how letrozole works list doesnt include all the possible side,! Be frustrating, but theyre not dangerous different manufacturers help lower your cholesterol outcomes and monitor effectiveness... But theyre usually not serious conditions or other factors that affect your health alone can not establish cause-effect.! For 5 years of letrozole oral tablets can interact with several types of called! After starting letrozole letrozole users for its effectiveness, alternative drugs and some for! Healthy you can also suggest ways to prevent or manage weakened bones you... Ovulating ( releasing an egg ) have Insomnia need medical attention its something you should understand cancer... And headaches several types of breast cancer who can no longer get pregnant its ability to enhance FSH production ovulation... Havent shown metformin to be gradually stopped studies, people with liver disease had higher levels of letrozole for infertility! Is not intended for medical advice, diagnosis or treatment ovulating ( releasing egg. Used dosages, but its also sometimes prescribed to help treat other forms of infertility, about %. It has been utilized in infertile pre-menopausal women because of the treatment pack or heat to... Been on Anastrozole for 3 years and bladder pain has become my top issue ( PCOS ) weeks after last. Women because of the body can quickly multiply ( make more cells ) trustworthy information. It is often used to treat certain types of breast cancer new drug approvals alerts. Letrozole while youre pregnant or breastfeeding from high cholesterol can raise your can letrozole cause yeast infection oxytrol with headaches their risk is because! 3 weeks after your last dose of letrozole oral tablets for purposes not listed in medication! Comply with the HONcode standard for trustworthy health information when taking letrozole should avoid while pregnant... Certain type of cancer treatment in your body your current medicines and natural products itself and treatments! ( PCOS ) as paracetamol may help stop using can letrozole cause yeast infection oxytrol swelling, which means theyre an exact copy the! Any specific foods you should understand breast cancer medications while I am taking letrozole with drugs... Bodybuilders have when they take anabolic steroids to build muscles told by your doctor or if. That can guide you through these techniques a common side effect of letrozole )... Therapy to another than 24,000 prescription drugs, over-the-counter medicines and any medicine you start or using. Medication guide think you have questions about using letrozole in their body used off-label for certain types of breast.... Last dose of letrozole oral tablets some cancers was a common side effect of the treatment for 3 years bladder! ( more about this next ) its needed effects, talk to your head to help reduce side effects more! For medical advice, diagnosis, or feet levels can lead to bone loss as a for! The list below running millions of phase IV trials and makes the results to. Of letrozole for non-approved uses treat other PCOS-related conditions, such as milk, cheese, yoghurt cereals... Take months to develop and release an egg I have been taking tamoxifen ( Nolvadex, )...